In 2003, the US Department of Agriculture Food and Drug Administration and the Slovenian Institute of Public Health jointly developed a new sample pretreatment technology based on MSPD technology. Anastassiades and Lehotay proposed solid phase extraction and matrix solid phase dispersion technology.
The detection method is a sample pretreatment technology which is quick, easy, cheap, effective, rugged and safe, called the QuEChERS method. It is essentially the combination and derivation of solid phase extraction and MSPD technology.
In 2004, in order to improve the recovery rate of certain alkali-sensitive pesticides, Lehotay et al. proposed a buffered QuEChERS method, in which acetonitrile containing 0.1% acetic acid is used as an extract, and anhydrous sodium acetate is used as a salting-out agent.